Contact Professor David Cullen

Areas of expertise


David Cullen graduated with a BSc in Biochemistry from the University of East Anglia and obtained his PhD in Biosensor Technology from the University of Cambridge. He continued postdoctoral studies in the same group before joining Cranfield University in 1994, initially as a lecturer in the area of Biophysics and Biosensors. Since 2008 he has been Professor of Bioanalytical Technology.

Current activities

The development and application of biosensors, bio-diagnostics and related bio-analytical technologies is the theme of Prof Cullen's past and current research. During the past decade, his main focus has been the design and application of such technologies in the field of astrobiology.

Recent and current projects include:
  • Joint lead-investigator for the Life Marker Chip (LMC) experiment for evidence of life detection on Mars as part of ESA's ExoMars rover mission (STFC / UKSA funded).
  • Development of the Bioscience, Astrobiology, Medical and Materials science experiments on CubeSats (BAMMsat) concept to exploit CubeSat platforms for bioscience and materials sciences experiments in LEO and beyond (UKSA funded).
  • Application and development of suites of in situ life detection and characterisation techniques for subglacial environments at the Svartisen Subglacial Laboratory in the Norwegian Arctic, Leverett Glacier in Western Greenland and glacial and volcanic sites in Iceland (EPSRC funded).
  • Use of stratospheric balloon platforms to study life in the upper atmosphere including design, build and flight of the Cranfield Astrobiological Stratospheric Sampling Experiment (CASS•E) instrument - flown twice in 2010 (partially ESA funded) and design and use of lightweight, low-cost high altitude balloon (HAB) platforms.
  • Study to confirm survivability of immunoassay reagents in simulated and real space environments including via the LMC experiment on ESA's Biopan-6 / Foton-M3 low-Earth orbit mission.
  • Development of the Hypervelocity Artificial Meteoroid Experiment (HAM•E) mission concept that proposes to enter >500kg of artificial meteoroid material into the Earth's atmosphere at >11km/s to contribute understanding to the evolution of the Early Earth and the current threat of Near Earth Objects.
  • Technology transfer of bioanalytical activities from extreme environment applications to those in medical, environmental, security and defence applications - currently sample processing for solid tissue biopsy samples.
  • Public outreach activities including schools lectures and appearances on radio and TV.


Public funding bodies including: BBSRC, EPSRC, STFC, UKSA, ESA and EC and funding from both national and international commercial sources.


Articles In Journals

Conference Papers

  • Gentry D, Amador ES, Cable ML, Cantrell T, Chaudry N, Duca ZA, Jacobsen MB, Kirby J, McCaig HC, Murukesan G, Rader E, Cullen T, Rennie V, Schwieterman EW, Stevens AH, Sutton SA, Tan G, Yin C, Cullen D, Geppert W & Stockton AM (2017) Quantifying variability and correlation in biomarker and mineralogical measurements: lessons from five astrobiological Mars analogue expeditions in Iceland. In: AGU Fall Meeting 2017: American Geophysical Union, New Orleans, 11-15 December 2017.
  • Juanes-Vallejo CM, Grama VV, Katramados I, Naicker L, Rato CC, Rix C, Sánchez-Camilo E, Patel MR & Cullen DC (2011) Cranfield astrobiological stratospheric sampling experiment (CASS•E): Overview of flight hardware configuration, implemented planetary protection and contamination control procedures and preliminary post-flight results. In: 20th ESA Symposium on European Rocket and Balloon Programmes and Related Research, Hyere, 22 May 2011.
  • Cullen DC & Roberts PCE (2011)

    The Hypervelocity Artificial Meteoroid Experiment (HAM.E): A Mission Concept Study

    . In: 74th Annual Meteoritical Society Meeting (2011), London, 8-12 August 2011.
  • Naicker L, Grama VV, Juanes-Vallejo CM, Katramados I, Rato C, Rix C, Sanchez E & Cullen D (2010) CASS•E: Cranfield astrobiological stratospheric sampling experiment. In: IAC2010 : 61st International Astronautical Congress, Prague, 27 September 2010.


  • Marks RS, Lowe CR, Cullen D, Weetall HH, Karube I (eds), (2007) Handbook of Biosensors and Biochips, Wiley-Interscience.
  • Cullen DC & Sims MR (2007) Life Detection within Planetary Exploration: Context for Biosensor and Related Bio-analytical Technologies. In: Handbook of Biosensors and Biochips, Wiley-Interscience.