Contact Dr Zhugen Yang
Areas of expertise
- Biomedical Engineering
- Biosensors & Diagnostics
- Environment and Health
- Food Safety
- Hazardous Substances
- Instrumentation, Sensors and Measurement Science
- Monitoring and Environmental Informatics
- Toxicology & Epidemiology
- Water Science and Engineering
Dr Zhugen Yang is a UK NERC Fellow and Lecturer (US Assistant Professor) in Sensor Technology, heading the sensors lab at Cranfield Water Science Institute (CWSI). The lab's mission is to explore the fundamental science and a wide range of applications in the water sector, environmental health and biomedical diagnosis. He is a multidisciplinary researcher, and his main research interests focus on low-cost, rapid and point-of-use sensors and devices for environmental science (e.g. microbial contamination in drinking water), public health (e.g. illicit drug of abuse), and biomedical diagnostics (e.g. infectious disease and cancer).
Dr Yang received a prestigious UK NERC Fellowship to start his independent academic career and established the Sensors for Environment and Health Research Group. He was appointed Lecturer at James Watt School of Engineering at the University of Glasgow before the group moved to Cranfield University. He was a Marie Curie Fellow at the University of Bath after completing a postdoc within the Department of Chemistry at the University of Cambridge. He earned his PhD in Micro and Nanotechnology from the University of Lyon (Ecole Centrale) in France, and his MSc (SYSU) and BEng (HIT) in China. He also held a visiting position at the Norwegian Institute of Water Research (NIVA) in Oslo, Norway.
His research has been sponsored with nearly £1 million, including funding from UK research councils (NERC, BBSRC), the Royal Academy of Engineering and the Scottish Partnership of Research Funds. The research output has led to over 30 referred articles (including high ranking journals such as PNAS, ACS Sensors, Analytical Chemistry, ES&T, Water Res), one book on microarray technology, one patent, and over 50 conference presentations.
PhD students, postdoctorates and visiting fellows
The Sensors for Environment and Health Research Group has consistently recruited talented PhD candidates in the areas of chemical, biological and microbial sensors, paper-microfluidics devices, molecular diagnosis, water quality, environmental health, analytical chemistry and illicit drugs of abuse. Please contact Dr Yang for futher discussion.
Currently, the group has no openings for postdoctorates but we are always keen to support talented scientists in applying the third funding source (e.g. Leverulme Trust, Royal Commission 1851, UK Newton fellowship, EU Marie Curie) to explore exciting areas of scientific research.
Master's and placements
If you are interested for an inter or short-term project (no shorter than three months), please contact Dr Yang for further discussion.
Dr Yang has developed a low-cost
paper origami device for rapid diagnosis of infectious disease and tested it in India, as well as using it to conduct tests for malaria in Uganda, Africa. He holds a prestigious
UKRC independent research fellowship,
which aims to develop easy-to-use paper-based devices for the rapid monitoring
of microbial contamination in drinking water, in collaboration with industry
partner Scottish Water (NE/R013349/1, £508k).
He also co-leads a BBSRC/NERC project (BB/S004335/1, £200k) focusing on the rapid diagnosis of infectious disease in agriculture (shellfish), in collaboration with the UK Centre for Environment Fisheries Aquaculture Science (CEFAS).
He is working on the development of low-cost sensors for the rapid monitoring of water quality in low- and middle-income countries, sponsored by the Royal Academy of Engineering (FoDSF\1819\1\8, £20k).
During his Marie Curie Fellowship, he proposed the unique concept of community sewage sensors and demonstrated them in the practical analysis of illicit drugs (e.g. cocaine) in wastewater to understand the community-level drug consumption pattern. This enabled a rapid and cost-effective way to monitor illicit drug use trends across Europe, in collaboration with EU SEWPROF and COST Action (ES1307).
NERC, BBSRC, Royal Academy of Engineering, Scottish Partnership of Research Funds, Scottish Water
Articles In Journals
- Mao K, Zhang H, Yang Z, (2020) Can a paper-based device trace COVID-19 sources with wastewater-based epidemiology?, Environmental Science and Technology, Available online 23 March 2020.
- Mao K, Min X, Zhang H, Zhang K, Cao H, Guo Y & Yang Z (2020) Paper-based microfluidics for rapid diagnostics and drug delivery, Journal of Controlled Release, Available online 10 March 2020.
- Castrignano E, Yang Z, Feil E, Bade R, Castiglioni S, Casuanilles A, Gracia-Lor E, Hernandez F, Plosz B, Ramin P, Rousis N, Ryu Y, Thomas K, de Voogt P, Zuccato E & Kasprzyk-Hordern B (2020) Enantiomeric profiling of quinolones and quinolone resistance gene qnrS in European wastewaters, Water Research, Available online 10 March 2020, Article No. 115653.
- Chang C, Chen C, Yin R, Shen Y, Mao K, Yang Z, Feng X & Zhang H (2020) Bioaccumulation of Hg in rice leaf facilitates selenium bioaccumulation in rice (Oryza sativa L.) leaf in the Wanshan mercury mine, Environmental Science and Technology, Available online 26 February 2020.
- Li P, Wang Z, Song R, Qian W, Wen P, Yang Z & He D (2020) Customizable fabrication for auxetic graphene assembled macrofilms with high conductivity and flexibility, Carbon, Available online 25 February 2020.
- Mao K, Zhang H, Wang Z, Cao H, Zhang K, Li X & Yang Z (2020) Nanomaterial-based aptamer sensors for arsenic detection, Biosensors and Bioelectronics, 148 (January) Article No. 111785.
- Reboud J, Xu G, Garrett A, Adriko M, Yang Z, Tukahebwa EM, Rowell C & Cooper JM (2019) Paper-based microfluidics for DNA diagnostics of malaria in low resource underserved rural communities, Proceedings of the National Academy of Sciences, 116 (11) 4834-4842.
- Mao K, Ma J, Li X & Yang Z (2019) Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors, Science of the Total Environment, 688 (October) 771-779.
- Yang Z, Xu G, Reboud J, Ali SA, Kaur G, McGiven J, boby n, Gupta P, Chaudhuri P & Cooper JM (2018) Rapid veterinary diagnosis of bovine reproductive infectious diseases from semen using paper-origami DNA microfluidics, ACS Sensors, 3 (2) 403-409.
- Castrignano E, Yang Z, Bade R, Baz-Lomba JA, Castiglioni S, Causanilles A, Covaci A, Gracia-Lor E, Hernandez F, Kinyua J, McCall AK, van Nuijs ALN, Ort C, Plosz BG, Ramin P, Rousis NI, Ryu Y, Thomas KV, de Voogt P, Zuccato E & Kasprzyk-Hordern B (2018) Enantiomeric profiling of chiral illicit drugs in a pan-European study, Water Research, 130 151-160.
- Alzahrani H, Antoine C, Aoki K, Baker L, Balme S, Bentley C, Bhattacharya G, Bohn PW, Cai Q, Cao C, Commandeur D, Crooks RM, Edwards M, Ewing A, Fu KY, Galeyeva A, Gao R, Hersbach T, Hillman R, Hu YX, Jiang L, Kanoufi F, Kranz C, Liu SC, Loffler T, Long YT, MacPherson J, McKelvey K, Minteer S, Mirkin M, Mount A, Nichols R, Nogala W, Ohl D, Qiu KP, Ren H, Rudd J, Schuhmann W, Siwy Z, Tian ZQ, Unwin P, Wang YX, Wilde P, Wu YF, Yang ZG & Ying YL (2018) Processes at nanoelectrodes: general discussion, Faraday Discussions, 210 235-265.
- Wei B, Mao K, Liu N, Zhang M & Yang Z (2018) Graphene nanocomposites modified electrochemical aptamer sensor for rapid and highly sensitive detection of prostate specific antigen, Biosensors and Bioelectronics, 121 41-46.
- Alzahrani H, Bentley C, Bohn PW, Chikere C, Commandeur D, Crooks RM, Ehi-Eromosele C, Ewing A, Galeyeva A, Hersbach T, Hillman R, Kanoufi F, Koper M, Kranz C, Loffler T, Long YT, MacPherson J, McKelvey K, Minteer S, Mirkin M, Nichols R, Nogala W, Ohl D, Pelta J, Ren H, Rudd J, Schuhmann W, Tian ZQ, Unwin P, Vezzoli A, Willets K, Wu YF, Yang ZG, Zhan DP & Zhao CA (2018) Energy conversion at nanointerfaces: general discussion, Faraday Discussions, 210 333-351.
- Alzahrani H, Bentley C, Burrows R, Cao C, Cai Q, Chikere C, Crooks RM, Dunevall J, Edwards M, Ewing A, Gao R, Hillman R, Kahram M, Kanoufi F, Kranz C, Lemineur JF, Long YT, McKelvey K, Mirkin M, Moore S, Nogala W, Ren H, Schuhmann W, Unwin P, Vezzoli A, White H, Willets K, Yang ZG & Ying YL (2018) Dynamics of nanointerfaces: general discussion, Faraday Discussions, 210 451-479.
- Mao K, Zhou Z, Han S, Zhou X, Hu J, Li X & Yang Z (2018) A novel biosensor based on Au@Ag core-shell nanoparticles for sensitive detection of methylamphetamine with surface enhanced Raman scattering, Talanta, 190 263-268.
- Rousis NI, Gracia-Lor E, Zuccato E, Bade R, Baz-Lomba JA, Castrignanò E, Causanilles A, Covaci A, de Voogt P, Hernàndez F, Kasprzyk-Hordern B, Kinyua J, McCall A, Plósz BG, Ramin P, Ryu Y, Thomas KV, van Nuijs A, Yang Z & Castiglioni S (2017) Wastewater-based epidemiology to assess pan-European pesticide exposure, Water Research, 121 (September) 270-279.
- Yang Z, Xu G, Reboud J, Kasprzyk-Hordern B & Cooper JM (2017) Monitoring genetic population biomarkers with wastewater-based epidemiology, Analytical Chemistry, 89 (18) 9941-9945.
- Gracia-Lor E, Rousis NI, Zuccato E, Bade R, Baz-Lomba JA, Castrignanò E, Causanilles A, Hernández F, Kasprzyk-Hordern B, Kinyua J, McCall A, van Nuijs ALN, Plósz BG, Ramin P, Ryu Y, Santos MM, Thomas K, de Voogt P, Yang Z & Castiglioni S (2017) Estimation of caffeine intake from analysis of caffeine metabolites in wastewater, Science of the Total Environment, 609 1582-1588.
- Gracia-Lor E, Castiglioni S, Bade R, Been F, Castrignano E, Covaci A, Gonzalez-Marino I, Hapeshi E, Kasprzyk-Hordern B, Kinyua J, Lai FY, Letzel T, Lopardo L, Meyer MR, O'Brien J, Ramin P, Rousis NI, Rydevik A, Ryu Y, Santos MM, Senta I, Thomaidis NS, Veloutsou S, Yang Z, Zuccato E & Bijlsma L (2017) Measuring biomarkers in wastewater as a new source of epidemiological information: Current state and future perspectives, Environment International, 99 131-150.
- Mao K, Yang Z, Li J, Zhou X, Li X & Hu J (2017) A novel colorimetric biosensor based on non-aggregated Au@Ag core–shell nanoparticles for methamphetamine and cocaine detection, Talanta, 175 338-346.
- Mao K, Yang ZG, Du P, Xu ZQ, Wang ZL & Li XQ (2016) G-quadruplex-hemin DNAzyme molecular beacon probe for the detection of methamphetamine, RSC Advances, 6 (67).
- Yang Z, Castrignano E, Estrela P, Frost CG & Kasprzyk-Hordern B (2016) Community sewage sensors towards evaluation of drug use trends: detection of cocaine in wastewater with DNA-directed immobilization aptamer sensors, Scientific Reports, 6 Article No. 21024.
- Yang Z, D'Uriac MA, Goggins S, Kasprzyk-Hordern B, Thomas KV, Frost CG & Estrela P (2015) A novel DNA biosensor using a ferrocenyl intercalator applied to the potential detection of human population biomarkers in wastewater, Environmental Science and Technology, 49 (9) 5609-5617.
- Yang Z, Kasprzyk-Hordern B, Goggins S, Frost CG & Estrela P (2015) A novel immobilization strategy for electrochemical detection of cancer biomarkers: DNA-directed immobilization of aptamer sensors for sensitive detection of prostate specific antigens, The Analyst, 140 (8) 2628-2633.
- Yang Z, Kasprzyk-Hordern B, Frost CG, Estrela P & Thomas KV (2015) Community sewage sensors for monitoring public health, Environmental Science and Technology, 49 (10) 5845-5846.
- Yang Z, Chevolot Y, Gehin T, Solassol J, Mange A, Souteyrand E & Laurenceau E (2013) Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: Application to the sensitive and specific detection of tumor markers from breast cancer sera, Biosensors and Bioelectronics, 40 (1) 385-392.
- Yang Z, Chevolot Y, Gehin T, Dugas V, Xanthopoulos N, Laporte V, Delair T, Ataman-Onal Y, Choquet-Kastylevsky G, Souteyrand E & Laurenceau E (2013) Characterization of three amino-functionalized surfaces and evaluation of antibody immobilization for the multiplex detection of tumor markers involved in colorectal cancer, Langmuir, 29 (5) 1498-1509.
- Sui N, Monnier V, Yang Z, Chevolot Y, Laurenceau E, Souteyrand E & Dugas V (2012) Preparation of core-shell silver/silica nanopaticles and their application for enhancement of cyanine 3 fluorescence, International Journal of Nanoscience, 11 (04) Article No. 1240020.
- Yang Z, Chevolot Y, Ataman-Onal Y, Choquet-Kastylevsky G, Souteyrand E & Laurenceau E (2012) Cancer biomarkers detection using 3D microstructured protein chip: Implementation of customized multiplex immunoassay, Sensors and Actuators B: Chemical, 175 22-28.
- Laurenceau E, Yang ZG, Chevolot Y, Attaman Y, Choquet-Kastylevsky G & Souteyrand E (2011) Tumor antigens titration on novel miniaturized immunoassay: 3D-Protein chip performance evaluation, Bulletin du Cancer, 98 S70-S70.
- Yang Z & Mai K (2011) Nonisothermal crystallization and melting behavior of beta-mucleated isotactic polypropylene and polyamide 66 blends, Journal of Applied Polymer Science, 119 (6) 3566-3573.
- Yang Z, Laurenceau E, Chevolot Y, Önal YA, Choquet-Kastylevsky G & Souteyrand E (2011) Cancer biomarkers detection using microstructured protein chip: implementation of customized multiplex immunoassay, Procedia Engineering, 25 952-955.
- Yang Z & Mai K (2010) Crystallization and melting behavior of beta-nucleated isotactic polypropylene/polyamide 6 blends with maleic anhydride grafted polyethylene-vinyl acetate as a compatibilizer, Thermochimica Acta, 511 (1-2) 152-158.
- Yang Z, Zhang Z, Tao Y & Mai K (2009) Preparation, crystallization behavior, and melting characteristics of beta-nucleated isotactic polypropylene blends with polyamide 6, Journal of Applied Polymer Science, 112 (1) 1-8.
- Yang Z, Chen C, Liang D, Zhang Z & Mai K (2009) Melting characteristic and beta-crystal content of beta-nucleated polypropylene/polyamide 6 alloys prepared using different compounding methods, Polymer International, 58 (12) 1366-1372.
- Zhang Z, Tao Y, Yang Z & Mai K (2008) Preparation and characteristics of nano-CaCO3 supported beta-nucleating agent of polypropylene, European Polymer Journal, 44 (7) 1955-1961.
- Yang Z, Zhang Z, Tao Y & Mai K (2008) Effects of polyamide 6 on the crystallization and melting behavior of P-nucleated polypropylene, European Polymer Journal, 44 (11) 3754-3763.
- Zhang Z, Wang C, Yang Z, Chen C & Mai K (2008) Crystallization behavior and melting characteristics of PP nucleated by a novel supported beta-nucleating agent, Polymer, 49 (23) 5137-5145.