Contact Dr Milena Dropa
Areas of expertise
- Water and Sanitation for Development
- Water Science and Engineering
Background
Dr Milena Dropa has been working on clinical and environmental antimicrobial resistance (AMR) since 2004. She is a researcher at the University of São Paulo, Faculty of Public Health. She has collaborated on diverse research projects focusing on the sanitary surveillance of various sources (clinical, food, environmental matrices), using Microbiology and Molecular Biology methods. During her MsC and PhD projects, she studied the spread of AMR through clinical and environmental Enterobacteriales. As a PhD, she was awarded a scholarship by the São Paulo Research Foundation (FAPESP) for the development of an international project on the biochemical characterization of a new protein, as well as for an independent research project on the detection and quantification of AMR genetic determinants in sewage samples from Brazil. She is currently a Research Fellow at Cranfield University, working on the project "Engineering Nature-based Solutions to Tackle Antimicrobial Resistance," coordinated by Dr. Tao Lyu.
Research opportunities
Milena is particularly interested in studying the dynamics of AMR bacteria and genes through clinical and natural environments.
Current activities
She is currently a Research Fellow at Cranfield University, working on the project "Engineering Nature-based Solutions (NbS) to Tackle Antimicrobial Resistance (AMR)," coordinated by Dr. Tao Lyu. The project has established a multidisciplinary partnership of experts in NbS, Environmental Chemistry, and AMR to evaluate and optimize constructed wetland technologies as NbS for wastewater treatment targeting emerging environmental challenges. She is also a researcher at the University of São Paulo, Faculty of Public Health, Brazil, where she has been developing several national and international research collaborations on AMR since 2004.
Publications
Articles In Journals
- Dropa M, da Silva JSB, Andrade AFC, Nakasone DH, Cunha MPV, .... (2024). Spread and persistence of antimicrobial resistance genes in wastewater from human and animal sources in São Paulo, Brazil. Tropical Medicine & International Health, 29(5)
- Santiago GS, Dropa M, Martone-Rocha S, dos Santos TP, de Moura Gomes VT, .... (2024). Antimicrobial resistance characterization of Enterococcus faecium, Enterococcus faecalis and Enterococcus hirae isolated from marine coastal recreational waters in the State of São Paulo, Brazil. Journal of Water and Health, 22(9)
- Araújo RSD, Barbosa MRF, Dropa M, Araujo de Castro VC, Galvani AT, .... (2024). Environmental surveillance of Cryptosporidium and Giardia in surface supply water and treated sewage intended for reuse from an urban area in Brazil. Environmental Pollution, 363(Pt 1)
- Breternitz BS, Dropa M, Martone-Rocha S, Ferraro PSP, dos Santos Peternella FA, .... (2024). Safe drinking water: to what extent are shallow wells reliable?. Journal of Water and Health, 22(11)
- de Oliveira VF, de Britto-Costa LF, de Aragão GL, Scaccia N, Mamana AC, .... (2024). Colonisation by multidrug-resistant organisms in health workers in primary care: narrow spectrum oral antimicrobials are a risk factor. European Journal of Clinical Microbiology & Infectious Diseases, 43(12)
- Sartori L, Sellera FP, Silva-Pereira TT, Fuga B, Fuentes-Castillo D, .... (2024). Gut colonization by extended-spectrum β-lactamase-producing Escherichia coli in dairy herd in Brazil: successful dissemination of a One Health clone. Veterinary Research Communications, 48(5)
- Sabino CP, Ribeiro MS, Wainwright M, dos Anjos C, Sellera FP, .... (2023). The Biochemical Mechanisms of Antimicrobial Photodynamic Therapy†. Photochemistry and Photobiology, 99(2)
- Pedro PM, Cullen Jr. L, Prado F, Uezu A, Piper R, .... (2023). Ecological monitoring using Collembola metabarcoding with extremely low bycatch amplification. Ecological Indicators, 157
- Daoud Z & Dropa M. (2023). Editorial: The global threat of carbapenem-resistant gram-negative bacteria, volume II. Frontiers in Cellular and Infection Microbiology, 13
- dos Anjos C, Leanse LG, Ribeiro MS, Sellera FP, Dropa M, .... (2023). New Insights into the Bacterial Targets of Antimicrobial Blue Light. Microbiology Spectrum, 11(2)
- Santos GAC, Dropa M, Martone-Rocha S, Peternella FAS, Veiga DPB, .... (2023). Microbiological monitoring of coagulase-negative Staphylococcus in public drinking water fountains: Pathogenicity factors, antimicrobial resistance and potential health risks. Journal of Water and Health, 21(3)
- Martone-Rocha S, Dropa M, Moreira Calixto da Cruz B, Belisário Mendes Oliveira Leite D, Pereira dos Santos T, .... (2023). Antimicrobial profile of non-typhoidal Salmonella isolated from raw sewage in the Metropolitan Region of São Paulo, Brazil. The Journal of Infection in Developing Countries, 17(01)
- Levin AS, Costa SF, Razzolini MTP, Padoveze MC, Nunes FLS, .... (2023). Launch of the São Paulo Wellcome Trust-funded multidisciplinary research program on optimising antimicrobial use in highly populated urban environments. The Lancet Regional Health - Americas, 25
- Dropa M & Daoud Z. (2022). Editorial: The global threat of carbapenem-resistant gram-negative bacteria. Frontiers in Cellular and Infection Microbiology, 12
- Barbosa MRF, Garcia SC, Bruni ADC, Machado FS, de Oliveira RX, .... (2022). One-year surveillance of SARS-CoV-2 in wastewater from vulnerable urban communities in metropolitan São Paulo, Brazil. Journal of Water and Health, 20(2)
- Davies YM, Cunha MPV, Dropa M, Lincopan N, Gomes VTM, .... (2022). Pandemic Clones of CTX-M-15 Producing Klebsiella pneumoniae ST15, ST147, and ST307 in Companion Parrots. Microorganisms, 10(7)
- Rojas MVR, Alonso DP, Dropa M, Razzolini MTP, de Carvalho DP, .... (2022). Next-Generation High-Throughput Sequencing to Evaluate Bacterial Communities in Freshwater Ecosystem in Hydroelectric Reservoirs. Microorganisms, 10(7)
- Bastos VK, Dropa M, Peternella FAS & Razzolini MTP. (2022). Detection of DNA from Toxoplasma gondii oocysts in water for reuse. Parasitology Research, 121(7)
- Ghiglione B, Haim MS, Penzotti P, Brunetti F, D´Amico González G, .... (2021). Characterization of Emerging Pathogens Carrying blaKPC-2 Gene in IncP-6 Plasmids Isolated From Urban Sewage in Argentina. Frontiers in Cellular and Infection Microbiology, 11
- Pepe Razzolini MT, Funada Barbosa MR, Silva de Araújo R, Freitas de Oliveira I, Mendes-Correa MC, .... (2021). SARS-CoV-2 in a stream running through an underprivileged, underserved, urban settlement in São Paulo, Brazil: A 7-month follow-up. Environmental Pollution, 290
- Fuentes‐Castillo D, Esposito F, Cardoso B, Dalazen G, Moura Q, .... (2020). Genomic data reveal international lineages of critical priority Escherichia coli harbouring wide resistome in Andean condors (Vultur gryphus Linnaeus, 1758). Molecular Ecology, 29(10)
- Santos GAC, Dropa M, Rocha SM, Peternella FAS & Razzolini MTP. (2020). Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) in drinking water fountains in urban parks. Journal of Water and Health, 18(5)
- de Araújo RS, Aguiar B, Dropa M, Razzolini MTP, Sato MIZ, .... (2018). Detection and molecular characterization of Cryptosporidium species and Giardia assemblages in two watersheds in the metropolitan region of São Paulo, Brazil. Environmental Science and Pollution Research, 25(15)
- Moura Q, Fernandes MR, Silva KC, Monte DF, Esposito F, .... (2018). Virulent nontyphoidal Salmonella producing CTX-M and CMY-2 β-lactamases from livestock, food and human infection, Brazil. Virulence, 9(1)
- Ghiglione B, Rodríguez MM, Curto L, Brunetti F, Dropa M, .... (2018). Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis. Antimicrobial Agents and Chemotherapy, 62(6)
- Zappelini L, Martone-Rocha S, Dropa M, Matté MH, Tiba MR, .... (2017). Effective characterization of Salmonella Enteritidis by most probable number (MPN) followed by multiplex polymerase chain reaction (PCR) methods. Environmental Science and Pollution Research, 24(5)
- Cunha MPV, Lincopan N, Cerdeira L, Esposito F, Dropa M, .... (2017). Coexistence of CTX-M-2, CTX-M-55, CMY-2, FosA3, and QnrB19 in Extraintestinal Pathogenic Escherichia coli from Poultry in Brazil. Antimicrobial Agents and Chemotherapy, 61(4)
- Pedro PM, Piper R, Bazilli Neto P, Cullen L, Dropa M, .... (2017). Metabarcoding Analyses Enable Differentiation of Both Interspecific Assemblages and Intraspecific Divergence in Habitats With Differing Management Practices. Environmental Entomology, 46(6)
- Cunha MPV, Davies YM, Cerdeira L, Dropa M, Lincopan N, .... (2017). Complete DNA Sequence of an IncM1 Plasmid Bearing the Novel qnrE1 Plasmid-Mediated Quinolone Resistance Variant and bla CTX-M-8 from Klebsiella pneumoniae Sequence Type 147. Antimicrobial Agents and Chemotherapy, 61(9)
- Nascimento T, Cantamessa R, Melo L, Fernandes MR, Fraga E, .... (2017). International high-risk clones of Klebsiella pneumoniae KPC-2/CC258 and Escherichia coli CTX-M-15/CC10 in urban lake waters. Science of The Total Environment, 598
- Dropa M, Lincopan N, Balsalobre LC, Oliveira DE, Moura RA, .... (2016). Genetic background of novel sequence types of CTX-M-8- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae from public wastewater treatment plants in São Paulo, Brazil. Environmental Science and Pollution Research, 23(5)
- Ulloa-Stanojlović FM, Aguiar B, Jara LM, Sato MIZ, Guerrero JA, .... (2016). Occurrence of Giardia intestinalis and Cryptosporidium sp. in wastewater samples from São Paulo State, Brazil, and Lima, Peru. Environmental Science and Pollution Research, 23(21)
- Ghiglione B, Rodríguez MM, Brunetti F, Dropa M, Curto L, .... (2016). Poblational and biochemical-structural analyses on CTX-M β-lactamases harboring the D240G mutation reveal that E. coli populations with decreased susceptibility to ceftazidime preexist under a multifactorial resistance profile. International Journal of Infectious Diseases, 53
- Fernandes MR, Moura Q, Sartori L, Silva KC, Cunha MPV, .... (2016). Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene. Eurosurveillance, 21(17)
- Fernandes MR, McCulloch JA, Vianello MA, Moura Q, Pérez-Chaparro PJ, .... (2016). First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil. Antimicrobial Agents and Chemotherapy, 60(10)
- Araújo* RS, Dropa M, Aguiar B, Pereira* A, Razzolini MTP, .... (2016). Quantification and molecular characterization of Cryptosporidium spp. from raw surface water and raw sewage for the monitoring of public water supplies in the metropolitan region of São Paulo, Brazil. ISEE Conference Abstracts, 2016(1)
- Dropa M, Ghiglione B, Matté MH, Balsalobre LC, Lincopan N, .... (2015). Molecular and Biochemical Characterization of CTX-M-131, a Natural Asp240Gly Variant Derived from CTX-M-2, Produced by a Providencia rettgeri Clinical Strain in São Paulo, Brazil. Antimicrobial Agents and Chemotherapy, 59(3)
- Dropa M, Balsalobre LC, Lincopan N, Matté GR & Matté MH. (2015). Complex class 1 integrons harboring CTX-M-2-encoding genes in clinical Enterobacteriaceae from a hospital in Brazil. The Journal of Infection in Developing Countries, 9(08)
- Ghiglione B, Rodríguez MM, Herman R, Curto L, Dropa M, .... (2015). Structural and Kinetic Insights into the “Ceftazidimase” Behavior of the Extended-Spectrum β-Lactamase CTX-M-96. Biochemistry, 54(32)
- Casella T, Rodríguez MM, Takahashi JT, Ghiglione B, Dropa M, .... (2015). Detection of blaCTX-M-type genes in complex class 1 integrons carried by Enterobacteriaceae isolated from retail chicken meat in Brazil. International Journal of Food Microbiology, 197
- Krzyzanowski F, Zappelini L, Martone-Rocha S, Dropa M, Matté MH, .... (2014). Quantification and characterization of Salmonella spp. isolates in sewage sludge with potential usage in agriculture. BMC Microbiology, 14(1)
- Oliveira S, Moura RA, Silva KC, Pavez M, McCulloch JA, .... (2014). Isolation of KPC-2-producing Klebsiella pneumoniae strains belonging to the high-risk multiresistant clonal complex 11 (ST437 and ST340) in urban rivers. Journal of Antimicrobial Chemotherapy, 69(3)
- Balsalobre LC, Dropa M & Matté MH. (2014). An overview of antimicrobial resistance and its public health significance. Brazilian Journal of Microbiology, 45(1)
- Dropa M. (2013). Disseminação da resistência a antimicrobianos em cepas clínicas e ambientais de Enterobacteriaceae: identificação e mapeamento do ambiente genético de genes codificadores de ESBL.
- Araújo RS, Dropa M, Fernandes LN, Carvalho TT, Sato MIZ, .... (2011). Genotypic Characterization of Cryptosporidium hominis from Water Samples in São Paulo, Brazil. The American Society of Tropical Medicine and Hygiene, 85(5)
- Rizek CF, Matté MH, Dropa M, Mamizuka EM, de Almeida LM, .... (2011). Identification of Staphylococcus aureus Carrying the mecA Gene in Ready-to-Eat Food Products Sold in Brazil. Foodborne Pathogens and Disease, 8(4)
- Rojas MVR, Matté MH, Dropa M, Silva MLD & Matté GR. (2011). Characterization of Vibrio Parahaemolyticus isolated from oysters and mussels in São Paulo, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 53(4)
- Martone-Rocha S, Piveli RP, Matté GR, Dória MC, Dropa M, .... (2010). Dynamics of Aeromonas species isolated from wastewater treatment system. Journal of Water and Health, 8(4)
- Dropa M, Balsalobre LC, Lincopan N, Mamizuka EM, Cassettari VC, .... (2010). Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and the class 1 integronassociated blaGES-7 in Brazil. Clinical Microbiology and Infection, 16(6)
- Balsalobre LC, Dropa M, de Oliveira DE, Lincopan N, Mamizuka EM, .... (2010). Presence of blaTEM-116 gene in environmental isolates of Aeromonas hydrophila and Aeromonas jandaei from Brazil. Brazilian Journal of Microbiology, 41(3)
- Dropa M, Balsalobre LC, Lincopan N, Mamizuka EM, Murakami T, .... (2009). Extended-spectrum beta-lactamases among Enterobacteriaceae isolated in a public hospital in Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 51(4)
- Balsalobre LC, Dropa M, Lincopan N, Mamizuka EM, Matté GR, .... (2009). Detection of metallo-β-lactamases-encoding genes in environmental isolates ofAeromonas hydrophilaandAeromonas jandaei. Letters in Applied Microbiology, 49(1)
- Cassettari VC, da Silveira IR, Dropa M, Lincopan N, Mamizuka EM, .... (2009). Risk factors for colonisation of newborn infants during an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in an intermediate-risk neonatal unit. Journal of Hospital Infection, 71(4)
- Balsalobre LC, Dropa M, Matté GR & Matté MH. (2009). Molecular detection of enterotoxins in environmental strains of Aeromonas hydrophila and Aeromonas jandaei. Journal of Water and Health, 7(4)
- Pavez M, Neves P, Dropa M, Matté MH, Grinbaum RS, .... (2008). Emergence of carbapenem-resistant Escherichia coli producing CMY-2-type AmpC β-lactamase in Brazil. Journal of Medical Microbiology, 57(12)
- Dropa M. (2006). Caracterização genotípica de cepas da família enterobacteriaceae produtoras de ß-lactamases de espectro estendido, isoladas de pacientes de um hospital da rede pública da cidade de São Paulo..