Contact Dr Jeff Pons
- Tel: +44 (0) 1234 988484
- Email: J.Pons@cranfield.ac.uk
- ORCID
Areas of expertise
- Ageing & Chronic Disease
- CBRN Focus Areas
- Counter-IED
- Drug Discovery & Development
- Explosives and Munitions
- Toxicology & Epidemiology
Background
Prior to joining Cranfield University, Dr JF Pons completed a PhD in organic chemistry from the University of Montpellier (France) in 1996 in the lab of Prof. Jean Martinez.
In 1997, he joined Prof. Andrew Parsons' group at the University of York for a two-year post-doctoral position in organic radical chemistry.
He then worked as a senior scientist, team leader, project leader at Evotec (a CRO in the pharmaceutical industry) for 16 years, where he was in charge of a number of medicinal chemistry projects across a variety of biological targets (cancer, viral, obesity...). Dr Pons was involved in a large diversity of chemistries, ranging from peptide, nucleoside and steroid to heterocyclic chemistry.
Publications
Articles In Journals
- Halleux F, Pons J, Wilson I, Simoens B, Van Riet R, .... (2023). Detonation performance of urea‐hydrogen peroxide (UHP)**. Propellants, Explosives, Pyrotechnics, 48(6)
- Halleux F, Pons J, Wilson I, Stennett C, Van Riet R, .... (2023). Urea‐Hydrogen Peroxide (UHP): Comparative study on the experimental detonation pressure of a non‐ideal explosive. Propellants, Explosives, Pyrotechnics, 48(10)
- Şen N, Pons J-F, Kurtay G, Yüksel B, Nazir H, .... (2023). New explosive materials through covalent and non-covalent synthesis: Investigation of explosive properties of trinitrotoluene: Acridine and picric acid: Acridine. Journal of Molecular Structure, 1292(November)
- Ugbeh Johnson J, Carpenter M, Williams C, Pons J-F & McLaren D. (2022). Complexities associated with nucleation of water and ice from jet fuel in aircraft fuel systems: A critical review. Fuel, 310(February)
- Halleux F, Pons J, Wilson I, Van Riet R & Lefebvre M. (2022). Small‐Scale Detonation of Industrial Urea‐Hydrogen Peroxide (UHP). Propellants, Explosives, Pyrotechnics, 47(2)
- Lefferts MJ, Humphreys LH, Mai N, Murugappan K, Armitage BI, .... (2021). ANFO vapour detection with conducting polymer percolation network sensors and GC/MS. The Analyst, 146(7)
- Lefferts MJ, Humphreys LH, Mai N, Murugappan K, Armitage BI, .... (2021). Ammonium Nitrate/Fuel Oil Vapour Detection with Conducting Polymer Percolation Network Sensors. ECS Meeting Abstracts, MA2021-01(56)
- Tennant M, Chew SC, Krämer T, Mai N, McAteer D, .... (2019). Practical Colorimetry of 3‐Nitro‐1,2,4‐Triazol‐5‐One. Propellants, Explosives, Pyrotechnics, 44(2)
- Chew SC, Tennant M, Mai N, McAteer D & Pons J. (2018). Practical Remediation of 3‐Nitro‐1,2,4‐triazol‐5‐one Wastewater. Propellants, Explosives, Pyrotechnics, 43(2)
- Niculescu-Duvaz D, Niculescu-Duvaz I, Suijkerbuijk BMJM, Ménard D, Zambon A, .... (2013). Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents. Bioorganic & Medicinal Chemistry, 21(5)
- Titchenell PM, Hollis Showalter HD, Pons J-F, Barber AJ, Jin Y, .... (2013). Synthesis and structure–activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Bioorganic & Medicinal Chemistry Letters, 23(10)
- Niculescu-Duvaz D, Niculescu-Duvaz I, Suijkerbuijk BMJM, Ménard D, Zambon A, .... (2010). Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. Bioorganic & Medicinal Chemistry, 18(18)
- Chang W, Du J, Rachakonda S, Ross BS, Convers-Reignier S, .... (2010). Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides. Bioorganic & Medicinal Chemistry Letters, 20(15)
- Napper AD, Hixon J, McDonagh T, Keavey K, Pons J-F, .... (2007). Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1.. Journal of Medicinal Chemistry, 50(5)
- Napper AD, Hixon J, McDonagh T, Keavey K, Pons J-F, .... (2005). Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. Journal of Medicinal Chemistry, 48(25)
- Parsons AF, Allan GM & Pons J-F. (2002). Tandem Radical Cyclisation and Translocation Approaches to Biologically Important Mitomycin Ring Systems. Synlett, 2002(9)
- Allan GM, Parsons AF & Pons J. (2002). Tandem Radical Cyclization and Translocation Approaches to Biologically Important Mitomycin Ring Systems.. ChemInform, 33(51)
- Pons J-F, Mishir Q, Nouvet A & Brookfield F. (2000). Thiazole formation via traceless cleavage of Rink resin. Tetrahedron Letters, 41(25)
- Baker SR, Burton KI, Parsons AF, Pons J-F & Wilson M. (1999). Tandem radical cyclisation of enamides mediated by tin hydride; pyrrolizidinone or indolizidinone ring formation. Journal of the Chemical Society, Perkin Transactions 1, 0(4)
- Baker SR, Burton KI, Parsons AF, Pons J & Wilson M. (1999). ChemInform Abstract: Tandem Radical Cyclization of Enamides Mediated by Tin Hydride; Pyrrolizidinone or Indolizidinone Ring Formation.. ChemInform, 30(28)
- Pons J-F, Fauchère J-L, Lamaty F, Molla A & Lazaro R. (1998). A Constrained Diketopiperazine as a New Scaffold for the Synthesis of Peptidomimetics. European Journal of Organic Chemistry, 1998(5)
- Richard Baker S, Parsons AF, Pons J-F & Wilson M. (1998). Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones. Tetrahedron Letters, 39(39)
- BAKER SR, PARSONS AF, PONS J & WILSON M. (1998). ChemInform Abstract: Tandem Radical Cyclizations Leading to Indolizidinones and Pyrrolizidinones.. ChemInform, 29(50)
- Lobaccaro C, Pons J-F, Duchesne M-J, Auzou G, Pons M, .... (1997). Steroidal Affinity Labels of the Estrogen Receptor. 3. Estradiol 11β-n-Alkyl Derivatives Bearing a Terminal Electrophilic Group: Antiestrogenic and Cytotoxic Properties. Journal of Medicinal Chemistry, 40(14)
Conference Papers
- Halleux F, Stennett C, Pons J-F, Wilson I, Van Riet R, .... (2023). Small-Scale Characterisation of Urea Hydrogen Peroxide Explosive Performance Using Heterodyne Velocimetry
- Halleux F, Pons JF, Wilson I, Van Riet R, Simoens B, .... (2022). Detonation performance of urea hydrogen peroxide
- Humphreys LH, Wilson IJ, McAteer D & Pons J-F. (2018). P1AP.8 - Development of Metal-Organic Framework (MOF) Sensors for Landmine Detection
- Titchenell PM, Pons J-F & Antonetti DA. (2012). Design, Characterization, and Structure-Activity Relationships of Substituted 2-Amino-4-Phenyl-Thiophenes as Novel Atypical Protein Kinase C Inhibitors for Diabetic Macular Edema
Books
- Halleux F, Stennett C, Pons J-F, Wilson I, Van Riet R, .... (2023). Small-Scale Characterisation of Urea Hydrogen Peroxide Explosive Performance Using Heterodyne Velocimetry In Future Developments in Explosives and Energetics. Royal Society of Chemistry.
- Mai N, Pons J, McAteer D & Gill PP. (2019). Global Approaches to Environmental Management on Military Training Ranges In Temple TJ & Ladyman MK (eds), Global approaches to environmental management on military training ranges. IOP Publishing.
- Pons J-F, Sow M, Lamaty F, Fauchére J-L, Molla A, .... (2002). New RGD amphiphilic cyclic peptide and new RGD-mimetic constrained diketopiperazines In Peptides Frontiers of Peptide Science. Springer Netherlands.