Contact Dr Charlene Greenwood
- Email: c.greenwood@cranfield.ac.uk
Background
After gaining her BSc degree in Forensic Science and Criminology from Keele University, Charlene continued her studies and gained an MSc degree in Forensic Anthropology and Archaeology from Cranfield University. Her PhD entitled 'Physicochemical Modifications to Bone Mineral' was awarded from Cranfield University and was winner of the Best Research Thesis Prize. Since gaining her PhD, Charlene has become an established researcher working collaboratively with internationally known individuals from both academia and industry. Charlene has gained experience across a range of archaeological, biomedical and forensic disciplines with good theoretical knowledge and practical applications.
Charlene's research focus has been to investigate the fundamental chemistry of biological apatites by employing a material science approach and her research has applications within archaeology, pharmaceutical, medical and forensic sectors. Charlene's contributions to archaeology involve unlocking the chemical information contained within bioarchaeomaterials such as cremated bone and dental calculus in order to reconstruct past diet and lifestyles (cooking and funerary practices). Her contributions to forensic research includes enhancing the understanding of changes to bone mineral chemistry during a fire scenario providing more information on the fire event as well as species differentiation. Charlene's main research interests focus on biomedical applications and currently involves material characterisation of diseased bone such as osteoporotic and osteoarthritic tissue for early diagnostic purposes.
Current activities
Charlene is a newly appointed Lecturer within Cranfield Forensic Institute, having previously worked on an ESPRC grant as a Research Fellow, which aimed to unlock the molecular information contained within X-ray scatter signatures from osteoporotic bone specimens. From this research, Charlene was able to formulate a preliminary model for fracture risk based on bone architecture and chemistry. The results from this project were used to secure more funding for development of technology from the EPSRC Institutional Sponsorship Fund.
She is currently working on an internationally collaborative project with Ryerson University Toronto, Ontario, Canada, investigating the physicochemical properties of bone from donors treated for osteoporosis. This project will not only focus on understanding the microarchitectural changes to bone using micro - computed tomography (µ - CT), but will also investigate the physicochemical properties of the bone, to evaluate the effectiveness of these medications. The findings will be examined alongside the elemental analysis carried out by the team at Ryerson.
Charlene also teaches on a variety of modules for the Forensic MSc Programme including Analytical Techniques, Trace Evidence, Fundamentals of Forensic Anthropology: Osteology (FFAO) and Further Forensic Anthropology: Identification (FAAI).
In 2017, Charlene was honoured to accept an invitation from the International Centre of Diffraction Data (ICDD), the world's most prestigious NFP diffraction data provider, to take up a Chair on their Bioceramic sub-panel. The ICDD is the predominant organisation providing support for powder diffraction labs around the world and therefore Charlene will be responsible for the way in which labs worldwide analyse their diffraction data for bioceramic materials.
Research Interests include:-
Biominerals
Diseased Bone
Heated Bone
The role of carbonate in the physicochemical properties of biological apatites
X-ray Diffraction (XRD)
Micro Computed Tomography (µ-CT) Imaging
Fourier Transform Infrared Spectroscopy (FTIR)
Publications
Articles In Journals
- Lyburn ID, Scott R, Cornford E, Bouzy P, Stone N, .... (2024). Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification. Heliyon, 10(6)
- Mohsin S, Brock F, Kaimala S, Greenwood C, Sulaiman M, .... (2023). A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT. PeerJ, 11
- Arnold EL, Elarnaut F, Downes D, Evans JPO, Greenwood C, .... (2023). Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation. Scientific Reports, 13(1)
- Gosling SB, Arnold EL, Davies SK, Cross H, Bouybayoune I, .... (2023). Microcalcification crystallography as a potential marker of DCIS recurrence. Scientific Reports, 13(1)
- Bouzy P, Lyburn ID, Pinder SE, Scott R, Mansfield J, .... (2023). Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer. Analytical Methods, 15(13)
- Arnold EL, Gosling S, Davies SK, Cross HL, Evans P, .... (2022). Thermally dynamic examination of local order in nanocrystalline hydroxyapatite. Journal of Solid State Chemistry, 315(November)
- Scott R, Lyburn I, Cornford E, Bouzy P, Stone N, .... (2022). Breast calcification micromorphology classification. The British Journal of Radiology, 95(1139)
- Arnold EL, Keeble DS, Evans JPO, Greenwood C & Rogers KD. (2022). Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite. Acta Crystallographica Section C Structural Chemistry, 78(5)
- Gosling S, Calabrese D, Nallala J, Greenwood C, Pinder S, .... (2022). A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications. The Analyst, 147(8)
- Cross HL & Greenwood CE. (2021). Effects of soft tissue on the crystallographic changes to bone mineral upon heating. Acta Crystallographica Section A Foundations and Advances, 77(a2)
- Gosling S, Calabrese D, Arnold E, Nallala J, Greenwood C, .... (2021). Breast calcification chemistry as a biomarker for progression of in-situ breast cancer. Bone Reports, 14
- Arnold EL, Keeble DS, Greenwood C & Rogers KD. (2020). New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites. Scientific Reports, 10(1)
- Arnold EL, Clement J, Rogers KD, Garcia-Castro F & Greenwood C. (2020). The use of μCT and fractal dimension for fracture prediction in osteoporotic individuals. Journal of the Mechanical Behavior of Biomedical Materials, 103
- McGivern H, Greenwood C, Márquez-Grant N, Kranioti EF, Xhemali B, .... (2020). Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?. Frontiers in Bioengineering and Biotechnology, 7
- Gosling S, Scott R, Greenwood C, Bouzy P, Nallala J, .... (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 24(4)
- Greenwood C, Clement J, Dicken A, Evans P, Lyburn I, .... (2018). Age-Related Changes in Femoral Head Trabecular Microarchitecture. Aging and disease, 9(6)
- Greenwood C, Clement J, Dicken A, Evans JPO, Lyburn I, .... (2016). Towards new material biomarkers for fracture risk. Bone, 93
- Dicken AJ, Evans JPO, Rogers KD, Stone N, Greenwood C, .... (2016). Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter. Scientific Reports, 6(1)
- Dicken AJ, Evans JPO, Rogers KD, Stone N, Greenwood C, .... (2015). X-ray diffraction from bone employing annular and semi-annular beams. Physics in Medicine and Biology, 60(15)
- Dicken AJ, Evans JPO, Rogers KD, Greenwood C, Godber SX, .... (2015). Energy-dispersive X-ray diffraction using an annular beam. Optics Express, 23(10)
- Greenwood C, Clement JG, Dicken AJ, Evans JPO, Lyburn ID, .... (2015). The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue. Bone Reports, 3
- Greenwood C, Rogers K, Beckett S & Clement J. (2013). Initial observations of dynamically heated bone. Crystal Research and Technology, 48(12)
- Greenwood C, Rogers K, Beckett S & Clement J. (2012). Bone mineral crystallisation kinetics. Journal of Materials Science: Materials in Medicine, 23(9)
Conference Papers
- Greenwood C, Rogers K, Wilson M, Lyburn I, Evans P, .... (2019). Developing focal construct technology for in vivo diagnosis of osteoporosis
- McGivern H, Greenwood C, Marquez-Grant N & Zioupos P. (2018). Getting to the bare bones of the age –related changes to the mechanical and structural properties of the clavicle
- Vachirawongsakorn V, Marquez-Grant N, Painter J, Beckett S & Greenwood C. (2018). Taphonomic processes of chop marks in terrestrial and buried environments: A micro-CT and stereo-microscopic study [poster]
- Greenwood C, Rogers K, Wilson M, Lyburn I, Evans P, .... (2017). Towards medical diagnostics using hyperspectral X-ray scatter
- Greenwood C, Rogers K, Dicken A, Evans P, Clement J, .... (2016). World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016): Poster Abstracts
- Greenwood C, Clement JG, Dicken AJ, Evans JPO, Lyburn ID, .... (2016). Fracture toughness of the cancellous bone of FNF femoral heads in relation to its microarchitecture
- Adams G, Cook RB, Greenwood C, Rogers KD & Zioupos P. (2015). Fracture toughness of cancellous bone: predictions from micro-CT values
- Armstrong JR, Greenwood C, Rogers KD & Zioupos P. (2014). Assessment of the physicochemical modifications to bone mineral caused by storage protocols