Dr Ibtisam E Tothill
Reader in Analytical Biochemistry; Head of Advanced Diagnostics and Sensors Group
Location: Cranfield Health, Vincent Building, Cranfield Campus
T: +44 (0)1234 758300 (Dept) +44 (0)7500 766487 (Mob)
Dr Sam Tothill (Reader in Analytical Biochemistry) leads the analytical biochemistry research activity within Cranfield Health and is Head of Advanced Diagnostics and Sensors Group at Cranfield University, with a group of approximately eight postgraduate students and postdoctoral researchers. Her current interests centre on the diagnostics arena, with research covering the medical, foods and environmental sectors and these include:
- Molecular recognition, sensing and diagnostics development
- Nanotechnology and its application in analytical and life sciences
- The use of bioinformatics tools for novel artificial receptor design and discovery
- Enzymology and biocatalysis
Dr Tothill’s expertise has been explored with a range of business clients nationally and internationally. Current and recent research has been supported by BBSRC, DEFRA, Oxoid Ltd, BRE, EA, MIRO, WRAP, the Institute for Medical Research and MARDI (Malaysia), Tupperware (USA), DuPont Ltd. (UK). Sierra Sensors (Germany), Philips Ltd., the European Commission (FP5, 6 &7) and collaborative research with NHS partner Hospitals (Bedford and Gloucester).
Sam has a PhD in Analytical Biochemistry from Cranfield University, where she conducted original research in enzyme catalysis and their application in biotechnology and diagnostics developments. She has MSc in Microbial Biochemistry and was awarded the top student award for her BSc degree.
Sam is a member of the Biochemical Society (UK), the editorial advisory board of the British Journal of Medical Practitioners (BJMP) and the Society of Authors, member of the Biosensors Special Interest Group (BioSIG) steering committee (Sensors and Instrumentation KTN). In addition she has served on the editorial board of the Journal of Biological physics and Chemistry (JBPC), as MSc Course Director, Deputy Education Director, Associate Dean for the Faculty of Medicine and Biosciences and as Director for the Sensors for Water Interest Group (SWIG).
Top five publications
- Uludag, Y. And Tothill, I.E. (2010). Development of a Sensitive Detection method of Cancer Biomarkers in Human Serum (75%) using a Quartz Crystal Microbalance Sensor and Nanoparticles amplification system. Talanta, 82, 277-282.
- Mustafa M.K., Nabok A., Parkinson D., Tothill I.E., Salam F., Tsargorodskaya A. (2010). Detection of ß- amyloid peptide (1-16) and amyloid precursor protein (APP770) using Spectroscopic Ellipsometry and QCM techniques: a step forward towards Alzheimers disease diagnostics. Biosens. Bioelectron., 26, 1332-1336.
- Ibtisam E. Tothill (2009). Biosensors for cancer markers diagnosis, Semin. Cell Dev. Biol., 20, (1), 55-62.
- Parker, C., Lanyon, Y., Manning, M. Arrigan, D. W. M. and Tothill I.E (2009). Electrochemical Immunochip sensor for Aflatoxin M1 detection. Anal. Chem., 81, 5291 -5298.
- Salam, F. and Tothill, I.E. (2009). Detection of Salmonella typhimurium using an electrochemical immunosensor, Biosens. Bioelectron., 24, 2630-2636.