Dr Lee Larcombe

Lecturer in Genetics and Computational Biology
Location: Cranfield Health, Vincent Building, Cranfield Campus
E: l.larcombe@cranfield.ac.uk
T: +44 (0)1234 758320

Current activities

Dr Lee Larcombe is a member of Cranfield Health's bioinformatics group, Course Director for the School’s MSc in Applied Bioinformatics and a London Technology Network business fellow. His research focus is broadly in the area of functional genomics; the exploration of the dynamics and regulation of transcription/translation and protein function from sequence information. He also has an interest in device development towards the diagnostic application of biomarkers; complementing the bioinformatic identification of targets.

Current research areas include:

Identification of novel gene promoter motifs for prediction of co-expression
Next Generation Sequence-based metagenomic microbial population analysis
Synthetic antigen peptide prediction for antibody and synthetic receptor targeting
Protein structure and function modelling for target identification/characterisation
Development of integrated chemoinformatic small molecule screening pipeline
Parallel and cluster computing for sequence alignment

External appointments

Business Fellow with the London Technology Network
Honorary Lecturer at Bangor University

Background

Lee gained his degree in 1998 in Genetics from Queen Mary, University of London, subsequently joining Cranfield University as a research assistant working on an EU-funded microarray development project and a DEFRA-funded scrapie prion modelling project. In 2001 he left the University, developing a small, but successful informatics consultancy interfacing with the bio/pharmaceutical sector. Having gained experience in a commercial environment, he made the decision to return to the University in 2004, gaining a PhD developing computational methods for the prediction of antigenic peptides for use in diagnostic and therapeutic antibody development in 2006.

Key Collaborators

Bangor University, Open University, Wellcome Trust Sanger Institute, National Physical Laboratory, GlaxoSmithKline, UK Home Office, Pfizer, HFL Quotient Bioresearch, Babraham Institute, Unilever.