Mr Mikko Finnilä
Location: Shrivenham campus
Department of Engineering and Applied Science
Current activities
Mikko Finnilä first arrived in Cranfield University in 2006 to pursue analysis of bone samples for his Master Thesis. At time it was discovered that the exposure to 2,3,7,8-Tetrochlorodibenzo-p-dioxin (TCDD) during development affects the material properties of bone, thus delaying the maturation of bone tissue. Since then the collaboration was further expanded to the characterization of the role of Aryl Hydrocarbon Receptor in bone toxicity after exposure to TCDD. This work has been conducted in collaboration with the University of Oulu, the National Institute of Health and Welfare, and the Karolinska Institute.
In addition to bone toxicity, Mr Finnilä has been involved in the characterization of the role of alkaline phosphatases in bone mineralization and growth in relation to material properties and bone strength. This work is now being conducted in collaboration with Roslin Institute, Edinburgh; the Sanford-Burnham Institute for Medical Research, La Jolla and the Universities of Glasgow and Oulu.
Mr. Finnilä is also involved in other studies of ecophysiological regulation of bone density and biomechanics in wildlife, where we have been looking for clues of how wildlife species can preserve their bone mass during winter sleep in projects managed by Dr. Petteri Nieminen and Dr. Anne-Mari Mustonen from University of Eastern Finland.
Mikko A.J. Finnilä has received funding from National Graduate School of Musculoskeletal Disorders and Biomaterials and Glasgow Research Partnership in Engineering.
In 2009 he received funding from The Yrjö Jahnsson Foundation to allow him to conduct his work at Cranfield University. He is also member of European Calcified Tissue Society and European Society for Biomaterials.
Background
In 2008 Mikko A.J. Finnila graduated as Master of Health Science in Medical and Wellness Technology with a major in Biomedical Technology from the Faculty of Medicine, University of Oulu. He is currently on a PhD programme at University of Oulu and University of Glasgow.
Selected publications
Master´s thesis:
Finnilä M.A.: Effects Of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure On Bone Material Properties From Macrostructure To Nanostructure, Master Thesis, University of Oulu, 2008
Full papers:
Huesa C., Yadav M.C., Finnilä M.A., Goodyear S.R., Robins S.P., Tanner K.E., Aspden R.M., Millán J.L., Farquharson C.. PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone. Epub 2011 Jan 25
Nieminen P., Finnilä M.A., Tuukkanen J., Jämsä T., Mustonen A.M., Preservation of bone mass and biomechanical properties during winter sleep—the raccoon dog (Nyctereutes procyonoides) as a novel model species. Bone. Epub 2010 Dec 10
Finnilä M.A., Zioupos P., Herlin M., Miettinen H.M., Simanainen U., Håkansson H., Tuukkanen J., Viluksela M., Jämsä T.:Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure on Bone Material Properties J Biomech. 2010 Apr 19;43(6):1097-103
Isaksson H., Tolvanen V., Finnilä M.A., Iivarinen J., Turunen A., Silvast T.S., Tuukkanen J., Seppänen K., Arokoski J.P.A., Brama P.A., Jurvelin J.S., Helminen H.J.: Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix. Exp Gerontol. 2009 Nov;44(11):708-17
Isaksson H., Tolvanen V., Finnilä M.A., Iivarinen J., Turunen A., Silvast T.S., Tuukkanen J., Seppänen K., Arokoski J.P.A., Brama P.A., Jurvelin J.S., Helminen H.J.: Physical exercise improves properties of bone and its collagen network in growing and maturing mice. 1: Calcif Tissue Int. 2009 Sep;85(3):247-56.
Abstracts:
Finnilä M.A., Herlin M., Zioupos P., Risteli J., Miettinen H.M., Korkalainen M., Jämsä T., Tuukkanen J., Håkansson H., Viluksela M.: Gender-Spesific Modulation of Bone Remodelling by 2,3,7,8-Tetrachlorodibenze-p-Dioxin Exposure and Ablation of Aryl Hydrocarbon Reseptor Alters Material Properties of Bone Matrix. The 3rd Joint Meeting of ECTS & IBMS 2011.
Huesa C., Yadav M.C., Finnilä M.A., Goodyear S.R., Robins S.P., Tanner K.E., Aspden R.M., Millán J.L., Farquharson C.: PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. The 37th Symposium on Calcified Tissues, Glasgow 2010.
Finnilä M.A., Huesa C., Yadav M.C., Zhu W., Millán J.L., Farquharson C. and Tanner K.E. Decreased material properties of extracellular bone matrix in phospho1-/- hypomineralization model.The 37th Symposium on Calcified Tissues, Glasgow 2010.
Viluksela M., Heikkinen P., Van der Ven L., Miettinen H.M., Korkalainen M., Savolainen L., Lilienthal H., Adamsson A., Toppari J., Finnilä M.A., Tuukkanen J., Hamscher G., Andersson P.L., Schrenk D., Halldin K., Håkansson H.: Toxicological Profile of High Purity PCB 180 in Adult Rats, 46th Congress of the European Societies of Toxicology, Dresden, 2009
Herlin M., Aula A., Miettinen H.M., Korkalainen M., Finnilä M., Tuukkanen J., Håkansson H., Viluksela M.: The Role of AhR in Dioxin-induced Modulation of Bone Microarchitecture and Mechanical Strength, 46th Congress of the European Societies of Toxicology, Dresden, 2009
Elabbas L., Stern N., Trossvik C., Finnilä M.A.J., Bowers J.W., Nakai J., Chu I., Tuukkanen J., Åkesson A., Håkansson H.: In utero and Lactational Exposure of Rats to a Mixture of Environmental Contaminants Detected in Canadian Arctic Human Populations: Changes in Bone Tissue Composition, Dimension and Biomechanics, 46th Congress of the European Societies of Toxicology, Dresden, 2009
Finnilä M., Zioupos P., Tuukkanen J., Viluksela M., Jämsä T.: Effects Of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure On Bone Nanomechanical Properties, 16th Congress of European Society of Biomechanics, Lucerne, 2008
