Dr Phil Bennett
Molecular Geneticist,
Location: Shrivenham campus
E: p.bennett@micropathology.com
T: +44 (0) 2476 323222
Department of Engineering and Applied Science
Current activities
Dr Bennett joined Micropathology Ltd in 2001 as the company’s Molecular geneticist and applied his past research experience into areas with a diagnostic service demand. These now include the clinical molecular analyses of bacteria and certain viruses, such as Hepatitis B, C and HIV, human genetic disorders and the forensic identification of severely compromised human remains.
Background
Graduating from Birmingham University in 1992 with a degree in Medical Biochemistry. Dr Bennett went on to spend five years in the Departments of Medicine and Neurology at the Queen Elizabeth Hospital in Birmingham, where he obtained his PhD in Neurogenetics, and completed a Post Doctoral Fellowship. Continuing these research interests, his second Post Doctoral Fellowship was in the newly formed Department Molecular Psychiatry, where he obtained extensive experience in DNA Microsatellite analysis.
Selected publications
Li C, Lu L, Wu X, Wang C, Bennett P, Lu T, Murphy D. (2009)Complete genomic sequences for hepatitis C virus subtypes 4b, 4c, 4d, 4g, 4k,4l,4m,4n,4o,4p,4q,4r and 4t. J Gen Virol. 90(Pt 8):1820-6.
Kuntzen T, Berical A, Ndjomou J, Bennett P, Schneidewind A, Lennon N, Birren BW, Kuiken C, Henn MR, Simmonds P, Allen TM. (2008) A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame.
J Med Virol. 80(8):1370-8
Poon A.F.Y, Kosakovsky Pond S.L, Bennett P, Richman D.D, Leigh Brown A.J, Frost S.D.W. (2007) Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus. PLoS Pathogens Vol. 2, No. 12, e127.
Lambert D, Middle F, Hamshere ML, Segurado R, Raybould R, Corvin A, Green E, O'Mahony E, Nikolov I, Mulcahy T, Haque S, Bort S, Bennett P, Norton N, Owen MJ, Kirov G, Lendon C, Jones L, Jones I, Holmans P, Gill M, Craddock N. (2005) Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. Mol Psychiatry. 10(9):831-41.
Hamshere ML, Bennett P, et al. (2005) Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry. 62(10):1081-8.
Bennett P. (2003) DNA Sequencing and the Human Genome Project. Chapter in Molecular and Cellular Pathology. Edited by Prof J. Crocker. Pubs. J.Wiley
Segurado R, Bennett P, et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet.73(1):49-62. Epub 2003 Jun 11.
Bennett P, Segurado R, Jones I, Bort S, McCandless F, Lambert D, Heron J, Comerford C, Middle F, Corvin A, Pelios G, Kirov G, Larsen B, Mulcahy T, Williams N, O'Connell R, O'Mahony E, Payne A, Owen M, Holmans P, Craddock N, Gill M. (2002) The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Mol Psychiatry 7(2):189-200
Bennett, P. (2000) Microsatellites Demystified! Journal Of Clinical Pathology-Clinical Molecular Pathology Edition 50(3):177-183
Vanacore, N., Bonifati, V., Fabrinni, G., Colosimo, C., Marconi, R., Nicholl, D., Bonuccelli, U., Stocchi, F., Lamberti, P., Volpe, G., De Michele, G., Iavarone, I., Bennett, P., Vieregge, P., Meco, G., For the European Study Group on Atypical Parkinsonisms. (2000) Smoking Habits in multiple system atrophy and progressive supranuclear palsy. Neurology 54:114
Nicholl, D.J., Bennett, P., Hiller, L., Bonifati, V., Vanacore, N., Fabbrini, G., Marconi, R., Colosimo, C., Lamberti, P., Stocchi, F., Bonuccelli, U., Vieregge, P., Ramsden, D.B., Meco, G.,Williams, A.C. (1999) A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. Neurology 53(7):1415-1421
Bonifati, V., Joosse, M., Nicholl, D.J., Vanacore, N., Bennett, P., Rizzu, P., Fabbrini, G., Marconi, R., Colosimo, C., Locuratolo, N., Stocchi, F., Bonuccelli, U., DeMari, M., Wenning, G., Vieregge, P., Oostra, B., Meco, G., Heutink, P. (1999) The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian cases. Neuroscience Letters 274(1):61-65
Bennett, P., Bonifati, V., Bonuccelli, U., Colosimo, C., De Mari, M., Fabbrini, G., Marconi, R., Meco, G., Nicholl, D.J., Stocchi, F., Vanacore, N., Vieregge, P. and Williams, A.C. on behalf of the ESGAP consortium. (1998) Direct genetic evidence for involvement of Tau in Progressive Supranuclear Palsy. Neurology 51(4):982-985
Bennett, P., Nicholl, D.J. (1998) Absence of the G209A mutation in the á-synuclein gene in British familes with Parkinson's Disease. Neurology 50(4):1183
Bennett, P., Mulcahy, T., Owen, M.J., Craddock, N., Gill, M. (1998) The Wellcome Trust UK-Irish Bipolar Sib-pair Study: Chromosome 21. American Journal of Medical Genetics 81(6):541
Nicholl, D.J., Bennett, P. (1998) N-acetyltransferase 2 and Parkinson's disease. The Lancet 351:141-142
Smith M-L., Burnett D., Bennett P., Waring R.H., Brown H.M., Williams A.C. and Ramsden D.B. (1998) A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol. Biochimica et Biophysica Acta 1442(2-3):238-244
Nicholl, D., Bennett, P., Williams, A.C. (1997) The Genetic Component to Parkinson's Disease. Progress in Neurology and Psychiatry 1(1):10-12
Ramsden, D.B., Kapadi, A., Fitch, N.J.S., Farmer, M.J., Bennett, P., Williams, A.C. (1997) Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. Journal Of Clinical Pathology-Clinical Molecular Pathology Edition 50(5):269-271
Bennett, P., Ramsden, D. B., Williams, A. C. (1996) Complete Structural Characterization Of the Human Aryl- Hydrocarbon Receptor Gene. Journal Of Clinical Pathology-Clinical Molecular Pathology Edition 49(1):M12-M16
Nicholl, D. J., Bennett, P., Ramsden, D. B., Ho, S. L., Williams, A. C. (1996) The Hhal Polymorphism In the CYP2D6 Gene Is Not Associated With Parkinson's-Disease In a Caucasian Population. European Journal Of Neurology 2(6):580-582
Ho, S. L., McCann, K. P., Bennett, P., Kapadi, A. L., Waring, R. H., Ramsden, D. B., Williams, A. C. (1996) The Molecular-Biology of Xenobiotic Enzymes and the Predisposition to Idiopathic Parkinson's-Disease. Advances In Neurology 69:53-60
Hoda, F., Nicholl, D., Bennett, P., Arranz, M., Aitchison, K. J., Alchalabi, A., Kunugi, H., Vallada, H., Leigh, P. N., Chaudhuri, K. R., Collier, D. A. (1996) No Association Between Parkinson's-Disease and Low-Activity Alleles Of Catechol O-Methyltransferase. Biochemical and Biophysical Research Communications 228(3):780-784
Gasser, T., Supala, A., Wszolek, Z., Muller, P., Bennett, P., Pfeiffer, R.F., Calne, D. (1995) Genetic Linkage Studies in Autosomal Dominantly Inherited L-Dopa Responsive Parkinsonism. Neurology 242 (6suppl. 2):S16
